The CpG island methylator phenotype (CIMP): What’s in a name?
نویسندگان
چکیده
Depts. of a Epidemiology and b Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands; c; Dept. of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium; d; Dept. of Surgery, Orbis Medical Center, Sittard-Geleen, the Netherlands; e ; Dept. of Pathology, Leiden University Medical Center, Leiden, the Netherlands; f; Dept. of Neurology, Erasmus University Medical Center, Erasmus University, Rotterdam,The Netherlands; g; The Johns Hopkins University School of Medicine, Baltimore, USA
منابع مشابه
Unique DNA methylome profiles in CpG island methylator phenotype colon cancers.
A subset of colorectal cancers was postulated to have the CpG island methylator phenotype (CIMP), a higher propensity for CpG island DNA methylation. The validity of CIMP, its molecular basis, and its prognostic value remain highly controversial. Using MBD-isolated genome sequencing, we mapped and compared genome-wide DNA methylation profiles of normal, non-CIMP, and CIMP colon specimens. Multi...
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The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation of multiple CpG island loci. The concept of CIMP as a molecular carcinogenesis mechanism was consolidated by the identification of the serrated neoplasia pathway, in which CIMP participates in the initiation and progre...
متن کاملCpG Island Methylator Phenotype Aberrant Methylation in Gastric Cancer Associated with the Updated Version
Aberrant methylation of 5* CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in cancer. In colorectal cancer, a group of tumors is characterized by a hypermethylator phenotype termed CpG island methylator phenotype (CIMP), which includes methylation of such genes as p16 and hMLH1. To study whether CIMP is present in gastric cancer, the methylation st...
متن کاملAberrant methylation in gastric cancer associated with the CpG island methylator phenotype.
Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in cancer. In colorectal cancer, a group of tumors is characterized by a hypermethylator phenotype termed CpG island methylator phenotype (CIMP), which includes methylation of such genes as p16 and hMLH1. To study whether CIMP is present in gastric cancer, the methylation st...
متن کاملTitle page Title: The CpG island methylator phenotype correlates with long-range epigenetic silencing in colorectal cancer Running title: CIMP correlates with LRES in colorectal cancer
The CpG island methylator phenotype (CIMP), characterized by an exceptionally high frequency of methylation of discrete CpG islands, is observed in 18% to 25% of sporadic colorectal cancers (CRCs). Another hypermethylation pattern found in CRCs, termed LRES (long-range epigenetic silencing), is associated with DNA/histone methylation in three distinct gene clusters at chromosome 2q14.2, demonst...
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